Thus, to investigate the molecular mechanisms underlining DCA cytotoxicity in leukemic cells with dysfunctional p53, we selected three p53mutated B leukemic cell lines (MAVER, MEC-1, MEC-2), which exhibited a dose- and time-dependent cytotoxic response to DCA (Figure 1A) with IC50 values comparable to those assessed for primary p53wild-type and p53mutated B-CLL cells (Table 2). The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.