TP53 and B-cell chronic lymphocytic leukemia: Even though we have previously demonstrated that DCA activated the p53 pathway and promoted the transcription of several p53 target genes in p53wild-type B leukemic cells [15], we have here demonstrated that DCA induced the transcription of p21 also in a p53-independent manner in both primary p53mutated B-CLL patient cells and p53mutated/null leukemic cell lines.