The impact of exosomes on inflammatory cytokines and TGFβ being more pronounced in BMC, which very efficiently take up tumor exosomes, and being strongest after coculture with ASMLwt, but hardly seen with poorly binding ASML-CD151/Tspan8kd exosomes points towards exosomal CD151 and Tspan8 particularly contributing to exosome binding/uptake. The gene discussed is TSPAN8; the disease is neoplasm.