DDIT3 and gastric cancer: For example, ectopic expression of GADD153, which is also a putative target gene of AP-1, increases the sensitivity of MKN45 gastric cancer cells to VP-16, cisplatin, 5-fluorouracil, and docetaxel, indicating that augmented GADD153 expression and AP-1 binding activity promote apoptosis induced by anticancer drugs[37].