CYP27B1 and non-small cell lung carcinoma: In the study, we selected single nucleotide polymorphisms (SNPs) located in the protein coding or promoter regions from tagging SNPs, including rs3782130 and rs10877012 in CYP27B1, rs6068816 and rs4809957 in CYP24A1, rs11574129 in VDR, rs7041 in GC, and rs10741657 in CYP2R1. In addition to the analysis of risk associations with individual SNPs, we also evaluated gene-gene and gene-environment interactions, and examined the effects of SNPs on mRNA expression and their associations with NSCLC survival.