Comparing the genotypes between cases and controls, we found SNPs rs3782130 (CYP27B1), rs6068816 (CYP24A1), rs4809957 (CYP24A1) and rs7041 (GC) associated with lung cancer risk, and the associations included the G/G genotype of rs3782130 (adjusted OR=1.60; 95% CI: 1.09-2.34), T/T genotype of rs6068816 (adjusted OR=0.40; 95% CI: 0.26-0.60), A/A genotype of rs4809957 (adjusted OR=2.32; 95% CI: 1.40-3.87), and G/G genotype of rs7041 (adjusted OR=0.57, 95% CI: 0.35-0.93). The gene discussed is CYP27B1; the disease is lung carcinoma.