EMT induction triggered by SERPINB3, in particular, closely resembled the scenario observed by us [10] and others [11,31] in cancer cells of different origin exposed to hypoxic conditions, with hypoxia-induced EMT found to involve hypoxia-inducible factors (HIFs), a family of heterodimeric transcription factors acting as master regulators of homeostatic responses to low oxygen tension [5-8]. Here, SERPINB3 is linked to cancer.