Remarkably, SERPINB3, which has been identified in the present study as a HIF-2α specific target, has been reported to be able to inhibit apoptosis and to stimulate proliferation (through c-Myc activation) as well as EMT and increased invasiveness in cancer cells [27-29], features that fit well with the recently proposed prognostic relevance of SERPINB3 whose expression has been recently reported to be significantly associated with early tumour recurrence and worse clinical outcome [30]. Here, EPAS1 is linked to cancer.