SERPINB3 and colonic neoplasm: Up-regulation of SERPINB3 mRNA levels and protein synthesis as well as the delayed release of SERPINB3 protein in the extracellular medium was also detected in HT-29 human colon cancer cells exposed to identical conditions of hypoxia (Supplemental Figure 4A,B), suggesting that hypoxia-dependent up-regulation of SERPINB3 may be not limited to hepatic cancer cells.