Indeed, statistical analysis performed on the latter cohort revealed the existence of a positive linear correlation between SERPINB3 and HIF-2α transcripts in HCC specimens from such patients, and the highest levels of HIF-2α were found in the subgroup of patients with high SERPINB3, previously characterized for early tumor recurrence and poor prognosis. Here, SERPINB3 is linked to hepatocellular carcinoma.