CDH1 and esophageal squamous cell carcinoma: Moreover, we also detected β-catenin and E-cadherin expression levels in the ESCC tissues and paired adjacent normal mucosa (Fig. 6A), in the normal epithelial cells, β-catenin and E-cadherin showed unequivocal and strong membranous staining just above basal cell layer, whereas, in the basal cell layer, β-catenin located mainly in the nucleus.