The OER reaches a value superior to 1 for control and scrambled cells while it decreases to a value of respectively 0.99 and 0.73 for U87-shEPOR and U251-shEPOR cells, confirming the absence of TMZ drug resistance of glioma cells in hypoxic conditions when the EPOR expression is knock-down. This evidence concerns the gene EPOR and central nervous system cancer.