We generated the following two stable clones to verify the relevance of the modulation of Ca2+ homeostasis by p53 in the tumor environment: the mouse embryo fibroblast (MEF) p53−/− clone that was transduced with H-RASV12 (p53−/− clone) and the MEF p53−/− clone that was transduced with H-RASV12 with re-introduced wild type (wt) p53 (p53+/+ clone) (Fig. 1A). This evidence concerns the gene TP53 and neoplasm.