We assessed by immunohistochemistry the expression levels of the components of the DDR pathway (CHK1, CHK2, CDC25c) and their phosphorylated forms in three reactive lymphnodes, 27 cases of small lymphocyte lymphoma (SLL), 18 marginal zone lymphoma (MZL), 44 Hodgkin lymphoma (HL), 22 Burkitt lymphoma (BL), and 99 consecutive DLBCL cases diagnosed at our Institution from 2002 to 2011. This evidence concerns the gene CHEK2 and diffuse large B-cell lymphoma.