Components of the DDR pathway CHK1, CHK2 and CDC25c resulted to be expressed in 100% of B cell neoplasms and normal reactive follicles tested (Table 1) but only aggressive lymphomas (BLs and DLBCLs) showed a significant activation of DDR pathway, as demonstrated by the expression of CHK1, phosphorylated at ser 345, and CDC25c, phosphorylated at ser 216 (Table 1). Here, CHEK2 is linked to aggressive behavior.