On the other hand it is noteworthy that single agent PF-0477736 showed activity in TP53 mutant aggressive B-cell lymphoma cell lines and primary cells, and that combined treatment with PF-0477736 was able to revert resistance to doxorubicin in TP53 mutant cells (Figure S2). Here, TP53 is linked to B-cell non-Hodgkin lymphoma.