Our analysis of TCGA AML dataset although small, agrees overall with the larger global profiling results for HOX expression in AML: FLT3-mutated AMLs have higher HOXA9 expression [59], AMLs with mutant NPM1 also show aberrant HOXA9 expression [47], and the coordinate expression of three established members of a transcriptional complex—HOXA9, MEIS1, and PBX3—is common (Supp. Here, MEIS1 is linked to acute myeloid leukemia.