Hyperforin, the major constituent of hypericum, was also demonstrated to inhibit in-vivo neo-vascularization processes in an experimental murine tumor model as to influence in-vitro several key steps of angiogenesis, such as endothelial cell proliferation, differentiation and invasion as well as MMP-2 and urokinase-mediated extracellular matrix degradation [18]. The gene discussed is MMP2; the disease is neoplasm.