Our present study demonstrates that overexpression of miR-145 inhibits glioma cell proliferation, invasion, angiogenesis in vitro, and decreases glioma cell growth in an animal model, possibly through the mechanism of miR-145-related decrease of ADAM17 and EGFR protein expressions via the Erk/p-Erk pathway in U87 cells. Here, ADAM17 is linked to central nervous system cancer.