In this study, we found that knockdown of JARID2 antagonized TGF-ß-induced EMT of A549 lung cancer cell line and HT29 colon cancer cell line by inhibiting TGF-ß-dependent changes in expression of EMT-related genes such as CDH1, ZEB family and miR-200 family. The gene discussed is CDH1; the disease is malignant colon neoplasm.