Previously, we reported that KDM5B/PLU1/JARID1B, an H3K4 demethylase and one of the candidate oncogenes, down-regulated the expression of KAT5 and CD82 genes to increase cell invasion [6] and repressed the expression of microRNA-200 (miR-200) family, thereby promoting epithelial-mesenchymal transition (EMT) of cancer cells [7]. The gene discussed is KDM5B; the disease is cancer.