To determine if Ror2-High expressing tumors correlated with increased disease severity as seen with osteosarcoma [21], we analyzed to the TCGA dataset and found a significant increase in Ror2-High expressing tumors in both advanced tumor stage (T4) (P = 0.0098), which is associated with local invasion and late clinical stage (Stage III–IV) (P = 0.0322) (Fig. 5C & D). The gene discussed is ROR2; the disease is neoplasm.