However, the present study, which was designed to assess the hepatic transcriptome of animals undergoing a nonhazardous drinking paradigm, detected no steatosis, normal hepatic cholesterol and triglyceride levels and a suppression of steady-state mRNA levels of nine genes in the cholesterol synthesis pathway (Tables 2.3 and 2.4), including HMG-CoA reductase (Hmgcr) and sterol regulatory element binding transcription factor 1 (Srebf1). This evidence concerns the gene HMGCR and steatosis.