A heterozygous hotspot mutation in SRSF2 gene has been identified in hematologic malignancies with varying frequencies, including myelodysplastic syndrome (MDS) [12]–[16], acute myeloid leukemia (AML) [12], chronic myelomonocytic leukemia (CMML) [17], [18], primary myelofibrosis (PMF) [19], [20], and systematic mastocytosis [21]. The gene discussed is SRSF2; the disease is myelodysplastic syndrome.