PLVAP and Hepatic fibrosis: Sinusoidal capillarization may precede liver fibrosis, but it is unclear if it has the potential to initiate, directly or indirectly, fibrosis [51], [54] Our results appear to answer this question since in Plvap-/- mice the targeted null-mutation of an endothelial-specific molecule primarily induces the lack of sinusoidal fenestrations and only secondarily, directly or indirectly, leads to liver fibrosis.