We previously reported that three SNPs in this pathway were associated with rectal cancer survival, SEPN1 rs718391 (HR 1.67, 95% CI 1.11,2.51) and SEPX1 rs13331553 (HR 1.46 95%CI 1.07,2.00) and SEPX1 rs732510 (HR 1.68 95% CI 1.09,2.60) after adjustment for multiple comparisons using FDR. The gene discussed is MSRB1; the disease is rectal cancer.