In support, TNF-α is a significant predictor of insulin resistance during pregnancy [54]; IL-1β interferes with the insulin signalling pathway in adipose tissue from pregnant women [12] and human placenta [55]; and IL-6 stimulates trophoblast fatty acid accumulation [56] and increases trophoblast System A amino acid transporter activity and expression [57]. The gene discussed is IL1B; the disease is Insulin resistance.