To investigate if a cancer stem cell population could be detected in U-CH1 cells, the expression of CD133 and the activity of aldehyde dehydrogenase (ALDH), common markers of cancer stem cells [42], [43], [44], [45], [46], were examined in cells maintained in either normoxia or hypoxia, with our without the addition of rCCN2. Here, PROM1 is linked to cancer.