When the tau protein is hyperphosphorylated, it results in the detachment of tau from the microtubules, which destabilizes the axons and can lead to self-assembly of neurofibrillary tangles, a pathological hallmark of Alzheimer's diseases and other tauopathies [62], [63], [85]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.