In the present study, we found significant infiltration of donor leukocytes in the kidney, and that infiltration of CD3+ T-cells, CD8+ T-cells, CD4+ T-cells, and macrophages mediated renal inflammation with peritubular capillaritis, tubulitis, acute glomerulitis, and endarteritis in allogeneic BMT recipients with systemic acute GVHD. This evidence concerns the gene CD8A and acute graft versus host disease.