In addition, given that LKB1 functions in part to prevent CREB target gene activation [45], the decreased mutation frequency of STK11 (LKB1) in TTP-low lung adenocarcinomas compared to the TTP-high cohort corresponds with the observed decrease in CREB-target gene expression in TTP-low tumors. The gene discussed is CREB1; the disease is lung adenocarcinoma.