In the TCGA breast cancer dataset, TTP-low tumors are twice as likely to be ER-negative (ER-) or PR-negative (PR-) versus TTP-high tumors, indicating that hormone therapies commonly used to block estrogen activity might be less effective at impairing the growth of breast tumors with low TTP expression (Fig. 4A). Here, ZFP36 is linked to breast carcinoma.