Interestingly, though the role of TTP as an mRNA destabilizing AUBP predicted that TTP-target genes would be increased in the TTP-low cohort, the expression of all 50 of these signature genes is markedly reduced in TTP-low tumors compared to TTP-high tumors in the TCGA breast cancer, lung adenocarcinoma, lung squamous cell carcinoma and colon adenocarcinoma datasets (Table 2). This evidence concerns the gene ZFP36 and squamous cell lung carcinoma.