HK2 and neoplasm: Knockdown of PKM2 not only suppressed tumor growth in the livers (Fig. 3C) but also suppressed the growth of metastatic lesions found in the lungs as shown by the Xenogen imaging and expression of human genes HK2 in the mouse lung tissues (5/5 mice in NTC vs 3/5 mice in shPKM2) (Fig. 3D).