To validate the multivariate comparisons, we performed univariate analysis and found extraintestinal disease manifestations (EIM) including IBD-associated arthritis and uveitis were more common in IDO1 SNP patients (OR 9.89, CI 2.0–49.4 with P = 0.005 and FDR = 0.019). The gene discussed is IDO1; the disease is Arthritis.