Clinical variables entered after PSM were age, gender, tumor size, hepatitis B virus (HBV) infection status, Child-Pugh class, cirrhosis, total bilirubin, serum AFP level, alanine aminotransferase (ALT), aspartate aminotransferase (AST), prothrombin time, albumin and platelet count. This evidence concerns the gene F2 and Cirrhosis.