Lech-Maranda et al. observed a relationship between detectable IL-10 levels and age of >60, ECOG status of ≥2, advanced stage, bulky tumor mass, high LDH, high IPI score, ≥2 microglobulin, anemia, existence of B symptoms, low albumin, low CR rate, and shorter progression-free survival and OS [11]. This evidence concerns the gene IL10 and anemia.