FBN3 and polycystic ovary syndrome: This fact has been known since the early reports of PCOS (92, 93); however, these features of PCOS ovaries had not received much attention until recently when it was discovered that the fibrillin 3 gene, located in a genomic region associated with PCOS (94), is expressed in the penetrating stroma in human and bovine ovaries in the first trimester (95).