In skeletal development and disease CTGF (CCN2) is required for coordinating chondrogenesis and angiogenesis2, WISP1 (CCN4) is upregulated in OA3 and mutations in WISP3 (CCN6) cause progressive pseudorheumatoid dysplasia4, while NOV (CCN3) has roles in skeletal development5, regulation of osteogenesis6,7, bone regeneration8 and bone cancer.9 Here, CCN4 is linked to bone cancer.