By utilizing bone marrow transplant approaches, one report has found that miR-155 promotes the development of atherosclerotic plaques in the ApoE-/- model by driving an NF-κB-dependent pro-inflammatory response (Nazari-Jahantigh et al., 2012), whereas another group has found that miR-155 inhibits atherosclerosis in the Ldlr-/- model by antagonizing the levels of circulating neutrophils and pro-inflammatory Ly6Chi monocytes (Donners et al., 2012). Here, APOE is linked to atherosclerosis.