NFKB1 and atherosclerosis: It is important to note that while inhibition of NF-κB activity in the endothelium reduces EC activation and atherogenesis (Gareus et al., 2008), antagonizing NF-κB in macrophages worsens atherosclerosis (Kanters et al., 2003), underscoring the diversity of NF-κB function in distinct tissues that are involved in atherogenesis.