HLA-DQB1 and type 1 diabetes mellitus: To examine the development of the gut microbiome in children at genetic risk for type 1 diabetes (T1D), DNA from 947 stool samples from 76 number children having the moderate (odds-ratio <5) to high risk (odds-ratio 5–15) for T1D according to their HLA-DQB1 genotype, which is known to increase T1D risk, was sequenced.