NOS1 and Hypoglycemia: VMH NO production by the neuronal NO synthase (nNOS) and NO signaling through its receptor, soluble guanylyl cyclase (sGC) are critical for both glucose sensing by GI neurons and the in vivo counterregulatory response (CRR) to hypoglycemia suggesting a role for these GI neurons in hypoglycemia detection (Murphy et al., 2009a; Fioramonti et al., 2010a, 2013).