This study has further confirmed association of JIA with seven genetic loci, six of which have now been replicated for the first time (C5orf56-IRF1 (rs4705862), ERAP2-LNPEP (rs27290), PRR5L (rs4755450), RUNX1 (rs9979383), RUNX3 (rs4648881), and UBE2L3 (rs2266959)). This evidence concerns the gene RUNX3 and juvenile idiopathic arthritis.