AFF3 and juvenile idiopathic arthritis: We have replicated the association of AFF3-LONRF2 (rs6740838), and showed suggestive association of ANKRD55 (rs71624119) and IL2-IL21 (rs1479924), which all had evidence of association with JIA prior to the Immunochip study [11–13], although the samples used in those prior studies significantly overlapped with those used in the Immunochip study (i.e. the replication efforts were not independent).