In duck myotubes, RIG-I, a viral RNA sensor of influenza virus induced by type I IFN (59), was modestly upregulated by LPAI H2N3 and HPAI H5N1 50-92 virus infection but downregulated by HPAI H5N1 tyTy05 virus, a strain that is lethal to young ducks (10) (Fig. 5G). This evidence concerns the gene RIGI and viral infectious disease.