These results are in line with the well-established link between disruption of proliferation, differentiation, and maturation of adult-born neurons and AD (Krezymon et al. 2013; Li et al. 2008; Shruster et al. 2010) and support a potential role for PPARγ in promoting granule cell maturation (Morales-Garcia et al. 2011; Wang et al. 2011). This evidence concerns the gene PPARG and Alzheimer disease.