Links among impaired brain insulin signaling, cognition, and AD are well established in rodent models (Bosco et al. 2011; Rodriguez-Rivera et al. 2011; Schioth et al. 2012; Talbot et al. 2012) and humans (Craft et al. 2012; Risner et al. 2006; Sato et al. 2011; Watson et al. 2005). Here, INS is linked to Alzheimer disease.