Although the wild-type embryos did not present any malformations (Fig. 3B), the gross morphology of the Daam1+/gt embryos was, generally, not substantially affected, as reported previously (Li et al., 2011), with eye defects in two out of 66 Daam1+/gt embryos (from two different litters) – one with asymmetric anophthalmia (only one eye affected) and one with microphthalmia (microphthalmia, Fig. 3D). The gene discussed is DAAM1; the disease is microphthalmia.