Hyperglycaemia affects the activity of important signalling pathways that are crucial for mouse embryogenesis, including the hypoxia (Hif1α), PDGFRa, Wnt-β-catenin (GSK3β, β-catenin) and the Wnt-planar cell polarity (PCP) (Vangl2, Daam1, Wnt5a, etc.)pathways (Pavlinkova et al., 2009). The gene discussed is VANGL2; the disease is Hyperglycemia.