However, the incidence of microphthalmia and anophthalmia observed as a consequence of Daam1 downregulation, together with the early detection of some Wnt-PCP genes in the main eye structures (e.g. the perioptic plexus, the optic cup, the optic nerve or the lens), strongly implicates this pathway in eye development. This evidence concerns the gene DAAM1 and Anophthalmia.