Maternal hyperglycaemia is known to affect the expression of components of the Wnt-PCP pathways, including Wnt5a, Vangl2, Rock1 and Daam1 in mouse embryos (Pavlinkova et al., 2009), suggesting that abnormal Wnt-PCP signalling might underlie diabetic embryopathies. The gene discussed is DAAM1; the disease is Hyperglycemia.