DAAM1 and craniorachischisis: However, we did not detect NTDs in association with diabetes, although interestingly, the only embryo that developed craniorachischisis (a characteristic phenotype of Wnt-PCP mutants) was a Daam1+/gt embryo that had been exposed to glucose, leading us to question whether this might have been provoked by the interaction between diabetes and the disruption of the Wnt-PCP pathway during neural tube development.