Among dozens of genes directly involved in DNA repair in humans [6], six of them have been previously studied in a wide series of Spanish PCa patients based on its relevance in the mechanism of the disease [7]: X-ray repair cross-complementing protein 1 (XRCC1), excision repair cross-complementing rodent repair deficiency, complementation group 2 (ERCC2), excision repair cross-complementing rodent repair deficiency, complementation group 1 (ERCC1), ligase IV (LIG4), ataxia telangiectasia mutated (ATM), and tumor protein p53 (TP53). Here, XRCC1 is linked to posterior cortical atrophy.