The finding of significantly reduced BMI in patients with LHA pathology is intriguing (see Figures 3 and 4) and suggests the possibility that pathology in this region may contribute to metabolic disturbances and weight loss in ALS, in addition to increased muscle work, possible mitochondrial defects [12], and dysphagia/bulbar symptoms [42]. The gene discussed is CGA; the disease is amyotrophic lateral sclerosis.