INSR and type 2 diabetes mellitus: Mitosis and cell cycle play an important role in the development of the disease[25, 26], the relation between Wnt and Type II diabetes is discussed in references[27–29], the disruption of ECM in diabetic kidneys and vascular system is well known (see, for example, references[30–32]), Sema domains are present in some insulin receptors (HGF, MSP)[33], while the connection between the immune system and diabetes is reviewed in[34].