Pathway analysis of DEPs among four NFPA subtypes demonstrated that ERK1/2, ERK, MAPK, GH1, Ras, and NF-κB were the key nodes in their pathway networks (Figure 4A-D); and the role of JAK2 in hormone-like cytokine signaling, growth hormone signaling, and ERK/MAPK signaling were signaling pathway networks in adenomas. Here, MAPK3 is linked to adenoma.