As shown in Figures 3D and E, similar to our findings using microarray analysis, FoxO was necessary for the cancer-induced upregulation of Cebpb, Fos, Fbxo31 and Psma2, and was necessary for the cancer-induced downregulation of Col6a2, Myoz3 and Tnc (interaction effect, p < 0.05, AAV9-ev C26 vs. AAV9-d.n.FoxO C26, p < 0.05). The gene discussed is FOS; the disease is cancer.