We also found that similar to the TA muscle, in response to cancer diaphragm muscles showed a significant downregulation of the collagen transcript, Col6a2, and Myoz3, which encodes the Z-disc-associated protein Myozenin 3, and that their downregulation was blocked in muscles transduced with AAV9-d.n.FoxO (Figure 4C). Here, MYOZ3 is linked to cancer.