Consistent with our observation, restoration of Let-7 expression has been found associated with reduction in tumor growth in those cancers in which the Let-7 family is globally decreased [34, 35], and a reduced expression of Let-7a was found associated with poor prognosis and shortened post-operative survival [19], thus suggestive of a tumor suppressive role of Let-7a during cervical carcinogenesis that may be manifested through control of aberrant STAT3 signaling. Here, STAT3 is linked to cancer.