These results were further emphasized by the analysis of gene expression data from a larger (N = 48) independent cohort of FLT3/ITD+ childhood AML patients [34], which demonstrated that HOXA and HOXB gene levels were significantly reduced in FLT3/ITD+ patients with PML-RARa (N = 12) compared to those without the fusion gene (N = 36; Figure 3B). Here, FLT3 is linked to acute myeloid leukemia.