Moreover, unsupervised hierarchical clustering based on HOX expression divided the leukemias into five main clusters characterized by the presence or absence of prevalent gene rearrangements, i.e., PML-RARa, RUNX1-RUNX1T1(AML1-ETO), CBFb-MYH11 and MLL alterations (Additional file 6: Figure S5). Here, RUNX1 is linked to leukemia.