In the multivariate Cox regression, the potential confounding factors of tumour size, tumour stage and grade, NPI status, PgR status, HER2 status and LVI determined by immunohistochemistry (with individual Kaplan-Meier statistics of P < 0.001 for all variables except tumour size (P = 0.036) and HER2 status (P = 0.003)) were included in the analysis (Table 2). This evidence concerns the gene PGR and neoplasm.