These findings have potential clinical relevance since mutations in NOTCH3 cause the late-onset genetic vascular condition, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) [34,35]. The gene discussed is NOTCH3; the disease is cerebral arteriopathy with subcortical infarcts and leukoencephalopathy.