Furthermore, a huge amount of cytokines and chemokines released by tumor cells or tumor-surrounding cells including IL-1β, IL-4, IL-6, IL-10, IFN-gamma, TGF-beta, CCL2, CCL5, S100A8, and S100A9, are reported to reprogram immature myeloid cells to became immunosuppressive MDSCs and to attract them in the tumor microenvironment (7, 64, 65). This evidence concerns the gene S100A9 and neoplasm.