Interestingly, the epithelial-specific splicing factors ESRP1 and ESRP2 (80) are markedly attenuated with EMT in the H358 model, but their expression is absent in both epithelial and mesenchymal A549 states, again indicating considerable heterogeneity in EMT programs within closely related NSCLC models. This evidence concerns the gene ESRP2 and non-small cell lung carcinoma.