RECQL and cancer: Remarkably, RECQ1 silencing significantly reduced proliferation of cancer cells as compared to normal cells in cell culture models and also suppressed tumor growth in mouse xenograft models (Sharma and Brosh, 2007; Futami et al., 2008a,b, 2010; Arai et al., 2011; Mendoza-Maldonado et al., 2011).