DDX3X and gallbladder cancer: In addition, recent study reported that positive DDX3 expression is significantly associated with large tumor size and high TNM (Tumor, Node, and Metastasis) stage, invasion, lymph node metastasis in gallbladder cancers (Miao et al., 2013), suggesting that DDX3 is a biomarker for metastasis and poor prognosis of gallbladder cancers.