Moreover, there is also a substantial body of evidence indicating involvement of mitochondria-associated oxidative stress, lipid signaling, Ca2+ dysregulation in normal aging, and the pathogenesis of common age-associated neurological diseases including AD and PD in which lipid peroxidation and PLA2 may be key partners (reviewed in Thibault et al., 2007; Mattson et al., 2008; Toescu and Vreugdenhil, 2010; Waldbaum and Patel, 2010). This evidence concerns the gene PLA2G6 and Alzheimer disease.