PLA2’s and deregulation of lipid metabolism are increasingly implicated in human age-, oxidative stress-, and inflammation-associated conditions including cardiovascular diseases and age-associated neurodegenerative diseases such as Alzheimer’s disease (Sun et al., 2004; Farooqui and Horrocks, 2006; Adibhatla and Hatcher, 2008; Sanchez-Mejia et al., 2008; Chalimoniuk et al., 2009; Sanchez-Mejia and Mucke, 2010; Desbene et al., 2012; Gentile et al., 2012; Hui, 2012; reviewed in Sun et al., 2014). Here, PLA2G2A is linked to early-onset autosomal dominant Alzheimer disease.