PLA2G6 and early-onset autosomal dominant Alzheimer disease: For instance, whereas many studies implicate PLA2 hyperactivity as a factor in the etiology of Alzheimer’s disease (Sanchez-Mejia and Mucke, 2010; Gentile et al., 2012; Hui, 2012), other studies suggest that hypoactivity of intracellular PLA2s (cPLA2 and iPLA2) are a contributing factor to memory impairment and Alzheimer’s neuropathology (reviewed by Schaeffer et al., 2009).